About SAM-e

S-Adenosylmethionine is a naturally-occurring sulphur-containing physiologic compound synthesized from the amino acid L-methionine and adenosine triphosphate. It is one of the most active methyl donors produced in the human body as well as an indirect precursor to glutathione and is involved in more than one hundred biochemical pathways and processes. More specifically, SAM-e supports positive mood, cognitive function, and helps keep the liver and joints healthy.

The SAM-e Gold Difference

SAM-e Gold features the biologically active S,S form, which is the form that mediates biochemical activity in the human body. The SAM-e used in SAM-e Gold is processed using a patented process that yields > 70% of the active pure S,S form.

Because SAM-e is inherently unstable and can be degraded by stomach acids, most commercially available brands include a number of preservatives and stabilizers (e.g. methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch) to protect the active ingredient and to support shelf-stability.

Because NutriGold is philosophically opposed to the use of synthetic and potentially harmful additives, the company spent over 2 years in R&D to formulate a SAM-e product that does not require enteric coating, can be encapsulated in a veggie capsule instead of requiring tableting, and is free of many of the synthetically processed additives and preservatives used in most commercially available SAM-e supplements.

The result is a clean-label SAM-e product that is standardized to the biologically active S,S isomer, shelf-stable, free of potentially harmful additives, certified vegan, certified kosher, and verified non-GMO through independent, real-time PCR testing.

Health Benefits of SAM-e

  • Supports positive mood and overall emotional wellness*
  • Supports liver function*
  • Supports healthy joints*
  • Supports healthy aging*

SAM-e Gold (200 mg, 60 veg caps)

SAM-e Gold (200 mg, 60 veg caps)
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Product ID: NGL4527
SAM-e Gold (Clean, Shelf-Stable Formula) - Liver, Joint, and Emotional Wellness Support - 200 mg (60 veg capsules) by NutriGold
List Price: $39.98
Sale Price: $29.99
You Save: $9.99 (25% off)
Availability: ***OUT OF STOCK***
  • SAM-e Gold Highlights
  • Biologically active form of SAM-e standardized to S,S isomer from fermentation of S. cerevisiae (baker's yeast)
  • No harmful processing aids or additives used during ingredient fermentation
  • Exceptionally pure, solvent-free manufacturing process
  • Verified free of corn, egg, gluten, milk, peanut, shellfish, and soy allergens by an independent lab
  • Verified non-GMO through supply-chain verification and real-time PCR testing by an independent lab
  • Does NOT contain fillers, binders, preservatives, stearates, laurates, sulfates, or dioxides
  • Does not contain methacrylic acid copolymer, glyceryl behenate, magnesium silicate, triethyl citrate, titanium dioxide, mannitol, glycerol palmitostearate, silicon dioxide, medium chain triglycerides, sodium carboxymethyl starch, or iron oxide
  • Certified kosher and vegan
  • 200 mg per veggiecapsule / 60 capsules per box
  • Manufactured to stringent cGMP standards
  • SAM-e Gold Key Health Benefits: Supports positive mood, cognitive function, and liver and joint health*

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Suggested Usage

As a dietary supplement, adults take one (1) capsule 1 to 2 times a day with a small meal, or as directed by a healthcare professional.

Supplement Facts
Serving Size: 2 veggie capsules
Servings per Container: 30

Amount per
% Daily
SAM-e (S-adenosylmethionine) 400 mg
†Daily Value not established


Do not use this supplement if you are pregnant or breastfeeding. Please consult a healthcare professional before taking this supplement if you are taking any medications. Product may cause gastrointestinal discomfort in some individuals. If symptoms persist, discontinue product use immediately. Store in original packaging away from moisture and direct sunlight. Keep out of reach of children.

Frequently Asked Questions

Does SAM-e Gold contain anything other than the active ingredients?
SAM-e Gold contains small amounts of calcium oxide, organic rice concentrate, and calcium chloride. Calcium oxide and calcium chloride are part of the ingredient complex and NOT added by NutriGold during manufacturing.

Is SAM-e Gold free of allergens?
SAM-e Gold is verified free of corn, egg, gluten, milk, peanut, shellfish and soy allergens by an independent lab.

Does SAM-e Gold contain any ingredients derived from GMOs?
SAM-e Gold does not contain any ingredients derived from GMOs and is verified non-GMO through supply-chain verification and real-time PCR testing by an independent lab.

Is SAM-e Gold suitable for vegans/vegetarians?
SAM-e Gold is certified vegan by Vegan Action.

How long do I have to take SAM-e Gold before I see any benefits?
Unlike OTC and prescription drugs that provide instant, temporary, symptomatic relief, dietary supplements provide progressive, long-term benefits by strengthening and supporting the body's natural defenses. Most supplements, including SAM-e Gold, may need to be taken for at least 6 to 8 weeks before the benefits of taking the supplement can be experienced. Please be advised that nutritional supplements work best when they are taken as part of a health maintenance program that includes a sensible diet rich in whole grains, fruits, and vegetables, a moderate exercise program, and the necessary lifestyle changes to support wellness.

What are the side effects, interactions, and/or contraindications, if any, associated with SAM-e Gold?
SAM-e may have side effects in a small percentage of people, such as gastrointestinal discomfort, dry mouth, headache, mild insomnia, sweating, dizziness, nervousness, and others, especially at higher doses. Individuals taking antidepressant medications, a dopamine promoter, pain medications, or any other OTC or prescription medication, should consult with their prescribing physician prior to using this product. Individuals who are pregnant, breastfeeding, and/or have been diagnosed with Parkinson's disease, bipolar disease or manic depression should not use SAM-e. Individuals with any other known or suspected medical condition, or those planning a medical procedure, should consult healthcare professional before beginning taking SAM-e.

Is SAM-e Gold safe for long-term use?
SAM-e Gold should be safe for long-term use as long as it taken as instructed and under the guidance of licensed medical professional.

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